After receiving a Premier Prix from the Conservatoire de Musique du Québec in Montreal, Julie-Anne Derome continued her training in England (1991-96) and the United States (1996). She rapidly came to public attention through her appearances at prestigious competitions at which she garnered several awards: the jury prize at the Concours Yehudi Menuhin in Paris (1992), and first prizes from the Mendelssohn Trust Award in England (1994) and the Emerson Quartet Competition in the United States (1995). In the midst of these competitions, in 1993, she performed Pierre Boulez's Anthèmes in the presence of the composer in Montreal.
Julie-Anne Derome has performed as guest soloist with a number of ensembles, including the Manchester Sinfonia (Aix-en-Provence). She gave the Canadian premieres of works by Jean Lesage and Luciano Berio with the Ensemble de la SMCQ, and world premieres of works by Denis Dion and Walter Boudreau (La Vie d'un héros) with the Nouvel Ensemble à Cordes, and the Orchestre Symphonique de Québec respectively. Derome also worked on a regular basis with the Emerson Quartet in 1995, moving on in 1996 to record an album of twentieth-century music for solo violin on the Atma label. This recording was warmly received by the critics, with the BBC Music Magazine hailing Derome as a %22rising star of the contemporary music repertoire%22.
As a founding member of the Trio Fibonacci, she has toured with the ensemble to the four corners of the planet. She has shared in the honours bestowed on the group, including a 2002 Prix Opus in the international achievement category. Since September of 2000, Julie-Anne Derome has performed on a Rocca (1902) violin entrusted to her use by the Canada Council for the Arts.